Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9636133 | 0.86 | KDM4E (0.40) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL10741861 | 0.85 | ALDH1A1 (0.35) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL9634311 | 0.84 | AURKA (0.45) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL9634988 | 0.81 | ALDH1A1 (0.43) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL9635662 | 0.81 | ALDH1A1 (0.46) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL9634404 | 0.81 | AURKA (0.43) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL9634512 | 0.81 | KDM4E (0.42) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL9634362 | 0.80 | HPSE (0.44) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL9634484 | 0.80 | PDE5A (0.45) | ALDH1A1KDM4EHPGDAURKAHPSE | |
| SCHEMBL7272368 | 0.79 | AURKA (0.48) | ALDH1A1KDM4ENPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |