Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9636242 | 0.90 | KDM4E (0.41) | KDM4EALDH1A1HPGDUSP2GAA | |
| SCHEMBL9634872 | 0.87 | KDM4E (0.41) | KDM4EALDH1A1HPGDUSP2GAA | |
| SCHEMBL9634705 | 0.82 | PDE5A (0.44) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL9636544 | 0.81 | HPSE (0.44) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL9636073 | 0.80 | PDE5A (0.43) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL9634861 | 0.80 | PDE5A (0.44) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL9636172 | 0.80 | PDE5A (0.46) | KDM4EALDH1A1HPGDUSP2GAA | |
| SCHEMBL9635744 | 0.80 | KDM4E (0.40) | KDM4EALDH1A1HPGDNPSR1MAPT | |
| SCHEMBL7270724 | 0.78 | PDE5A (0.50) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL9634414 | 0.78 | PDE5A (0.40) | KDM4EALDH1A1HPGDGAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |