Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635097 | 0.89 | KDM4E (0.41) | PDE5AALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL10742244 | 0.85 | ALDH1A1 (0.37) | PDE5AALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL9634705 | 0.85 | PDE5A (0.44) | PDE5AALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL9636073 | 0.83 | PDE5A (0.43) | PDE5AALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL9634861 | 0.83 | PDE5A (0.44) | PDE5AALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL9636132 | 0.82 | PDE5A (0.39) | PDE5AALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL9634872 | 0.81 | KDM4E (0.41) | PDE5AALDH1A1KDM4ERAB9ALDHA | |
| SCHEMBL7270724 | 0.81 | PDE5A (0.50) | PDE5AALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL9634988 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KDM4ENPC1RAB9ALDHA | |
| SCHEMBL9635764 | 0.78 | KDM4E (0.46) | PDE5AALDH1A1KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |