Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | FLT1 | P17948 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9636245 | 0.86 | KDM4C (0.39) | PDE5AKDM4EALDH1A1HPGDMETAP1 | |
| SCHEMBL9634651 | 0.85 | METAP1 (0.39) | PDE5AKDM4EALDH1A1HPGDMETAP1 | |
| SCHEMBL9636067 | 0.83 | FGFR1 (0.40) | PDE5AKDM4EALDH1A1HPGDMETAP1 | |
| SCHEMBL10742025 | 0.82 | PDE5A (0.37) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| SCHEMBL9634542 | 0.82 | PDE10A (0.39) | PDE5AKDM4EALDH1A1HPGDMETAP1 | |
| SCHEMBL9636529 | 0.82 | METAP1 (0.34) | PDE5AKDM4EALDH1A1HPGDMETAP1 | |
| SCHEMBL7271878 | 0.81 | PDE5A (0.57) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| SCHEMBL9634600 | 0.81 | PDE5A (0.40) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| Hydrochloric Acid SCHEMBL7278102 | 0.80 | PDE5A (0.58) | PDE5AKDM4EALDH1A1HPGDPDE3B | |
| Hydrochloric Acid SCHEMBL9838295 | 0.80 | PDE5A (0.41) | PDE5AKDM4EALDH1A1HPGDPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |