Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.54 |
| ▸ | PDE5A | O76074 | 7/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 4/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634492 | 0.91 | AURKA (0.63) | AURKAPDE5APRMT5NPY5RPDE2A | |
| SCHEMBL9635710 | 0.85 | PDE5A (0.56) | AURKAPDE5APRMT5NPY5RPDE4A | |
| SCHEMBL9635915 | 0.85 | AURKA (0.67) | AURKAPDE5APRMT5NPY5RPDE2A | |
| SCHEMBL9634908 | 0.83 | PRMT5 (0.65) | AURKAPRMT5PARP1METAP2METAP1 | |
| SCHEMBL9635725 | 0.82 | PDE5A (0.55) | AURKAPDE5APRMT5NPY5RPDE4A | |
| SCHEMBL9634857 | 0.82 | PDE5A (0.55) | AURKAPDE5APRMT5NPY5RPDE4A | |
| SCHEMBL711173 | 0.81 | AURKA (0.56) | AURKAPDE5APRMT5NPY5RPDE4A | |
| SCHEMBL9635743 | 0.81 | PDE2A (0.60) | AURKAPDE5APDE4APDE4BPDE4C | |
| SCHEMBL9635778 | 0.81 | PDE5A (0.63) | AURKAPDE5APDE4APDE4BPDE4C | |
| SCHEMBL9634842 | 0.81 | PDE5A (0.63) | AURKAPDE5APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |