Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 6/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 4/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635725 | 1.00 | PDE5A (0.55) | PDE5AMAPTMAOBAURKANPY5R | |
| SCHEMBL9635680 | 0.90 | AURKA (0.56) | PDE5AMAPTMAOBAURKANPY5R | |
| SCHEMBL9635658 | 0.90 | AURKA (0.56) | PDE5AMAOBAURKANPY5RPRMT5 | |
| SCHEMBL9635710 | 0.88 | PDE5A (0.56) | PDE5AAURKANPY5RPDE4APDE4B | |
| SCHEMBL9634821 | 0.86 | PARP1 (0.49) | PDE5AAURKANPY5RPRMT5PDE2A | |
| SCHEMBL9634352 | 0.84 | AURKA (0.48) | PDE5AAURKANPY5RPRMT5 | |
| SCHEMBL10908413 | 0.83 | PDE5A (0.61) | PDE5AAURKAPDE4APDE4BPDE4C | |
| SCHEMBL9635813 | 0.82 | AURKA (0.54) | PDE5AAURKANPY5RPDE4APDE4B | |
| SCHEMBL9635778 | 0.82 | PDE5A (0.63) | PDE5AAURKAPDE4APDE4BPDE4C | |
| SCHEMBL9636135 | 0.80 | AURKA (0.54) | PDE5AAURKAPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |