Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2470556 | 0.90 | ESR1 (0.47) | ESR1KDM4EALDH1A1GAAAKR1C3 | |
| SCHEMBL2470558 | 0.90 | ESR1 (0.47) | ESR1KDM4EALDH1A1GAAAKR1C3 | |
| SCHEMBL11306935 | 0.79 | EGFR (0.41) | ESR1KDM4EALDH1A1GAAAKR1C3 | |
| Diethylamine SCHEMBL10944799 | 0.79 | HDAC2 (0.54) | ESR1KDM4EALDH1A1AKR1C3FFAR1 | |
| SCHEMBL16975541 | 0.79 | FFAR1 (0.41) | ESR1ALDH1A1AKR1C3FFAR1MIF | |
| SCHEMBL16975540 | 0.79 | FFAR1 (0.41) | ESR1ALDH1A1AKR1C3FFAR1MIF | |
| SCHEMBL13262820 | 0.78 | ESR1 (0.54) | ESR1MIF | |
| SCHEMBL29550418 | 0.78 | ALDH1A1 (0.47) | ESR1KDM4EALDH1A1GAAMEN1 | |
| SCHEMBL16831995 | 0.78 | ALDH1A1 (0.47) | ESR1KDM4EALDH1A1GAAMEN1 | |
| SCHEMBL16831994 | 0.78 | ALDH1A1 (0.47) | ESR1KDM4EALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187295-B1 | PHOTOLITHOGRAPHIC METHOD | MicroSi, Inc. (a Delaware corporation) (US) | 1992-06-03 | — | — | EP | claimed |
| EP-0187295-A2 | Photolithographic method | MicroSi, Inc. (a Delaware corporation) (US) | 1986-07-16 | — | — | EP | claimed |
| US-4578344-A | Photolithographic method using a two-layer photoresist and photobleachable film | GENERAL ELECTRIC COMPANY (US) | 1986-03-25 | — | — | US | claimed |
| EP-0187295-B1 | PHOTOLITHOGRAPHIC METHOD | MicroSi, Inc. (a Delaware corporation) (US) | 1992-06-03 | — | — | EP | disclosed |
| EP-0188230-B1 | PHOTOLITHOGRAPHIC STRIPPING METHOD | MicroSi, Inc. (a Delaware corporation) (US) | 1991-01-09 | — | — | EP | disclosed |
| US-4623611-A | DISSOLVING WITH TOLUENE | GENERAL ELECTRIC COMPANY (US) | 1986-11-18 | — | — | US | disclosed |
| EP-0188230-A2 | Photolithographic stripping method | MicroSi, Inc. (a Delaware corporation) (US) | 1986-07-23 | — | — | EP | disclosed |
| EP-0187295-A2 | Photolithographic method | MicroSi, Inc. (a Delaware corporation) (US) | 1986-07-16 | — | — | EP | disclosed |
| US-4591546-A | Spin castable resist composition and use | GENERAL ELECTRIC COMPANY (US) | 1986-05-27 | — | — | US | disclosed |
| US-4578344-A | Photolithographic method using a two-layer photoresist and photobleachable film | GENERAL ELECTRIC COMPANY (US) | 1986-03-25 | — | — | US | disclosed |
| US-4535053-A | SPIN CASTING POLYMETHYL METHACRYLATE CONTAINING CINNAMIC ACID DERIVATIVE DYE | GENERAL ELECTRIC COMPANY (US) | 1985-08-13 | — | — | US | disclosed |