Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634643 | 0.88 | MAOB (0.49) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10742377 | 0.86 | HDAC6 (0.43) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9635551 | 0.85 | PKN1 (0.44) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9635672 | 0.84 | MAPT (0.56) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9634295 | 0.83 | HDAC6 (0.53) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9634499 | 0.82 | HDAC6 (0.49) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9636105 | 0.81 | HDAC6 (0.43) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9634527 | 0.81 | PDE5A (0.39) | KDM4EALDH1A1SMN1; SMN2NPC1HPGD | |
| SCHEMBL9635887 | 0.81 | AMY1A (0.38) | KDM4EALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL9635899 | 0.81 | MEN1 (0.53) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |