Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635660 | 0.90 | PDE5A (0.50) | PDE5APDE3BPDE3AGAAALDH1A1 | |
| SCHEMBL9634729 | 0.88 | PDE5A (0.48) | PDE5APDE3BPDE3AALDH1A1NFKB1 | |
| SCHEMBL9634654 | 0.85 | PDE5A (0.53) | PDE5APDE3BPDE3AALDH1A1KDM4E | |
| SCHEMBL10847776 | 0.83 | PDE5A (0.54) | PDE5APDE3BPDE3AALDH1A1TDP1 | |
| SCHEMBL9634292 | 0.83 | PDE5A (0.49) | PDE5APDE3BPDE3AALDH1A1KDM4E | |
| SCHEMBL10748751 | 0.83 | PDE5A (0.51) | PDE5APDE3BPDE3AALDH1A1KDM4E | |
| SCHEMBL10742502 | 0.82 | PDE5A (0.50) | PDE5APDE3BPDE3AALDH1A1KDM4E | |
| SCHEMBL9636125 | 0.82 | PDE5A (0.48) | PDE5APDE3BPDE3AGAAALDH1A1 | |
| SCHEMBL9634881 | 0.81 | PDE5A (0.51) | PDE5APDE3BPDE3AALDH1A1KDM4E | |
| SCHEMBL9634369 | 0.81 | PDE5A (0.49) | PDE5APDE3BPDE3AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |