Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635660 | 0.91 | PDE5A (0.50) | PDE5APDE3BPDE3AHSD17B10HPSE | |
| SCHEMBL9636129 | 0.88 | PDE5A (0.51) | PDE5APDE3BPDE3AHPSEKDM4E | |
| SCHEMBL9634814 | 0.84 | ADORA2B (0.48) | PDE5APDE3BPDE3AHSD17B10PKN1 | |
| SCHEMBL9634654 | 0.84 | PDE5A (0.53) | PDE5APDE3BPDE3AHSD17B10KDM4E | |
| SCHEMBL9634726 | 0.83 | PDE5A (0.46) | PDE5APDE3BPDE3AHSD17B10KDM4E | |
| SCHEMBL9635629 | 0.82 | PDE5A (0.44) | PDE5APDE3BPDE3APKN1PKN2 | |
| SCHEMBL10748751 | 0.79 | PDE5A (0.51) | PDE5APDE3BPDE3AHSD17B10HPSE | |
| SCHEMBL10742502 | 0.79 | PDE5A (0.50) | PDE5APDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL9634881 | 0.78 | PDE5A (0.51) | PDE5APDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL9634369 | 0.78 | PDE5A (0.49) | PDE5APDE3BPDE3AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |