Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.40 |
| ▸ | KYNU | Q16719 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL146329 | 0.93 | KDM4E (0.42) | KDM4EHIF1ATDP1ALDH1A1GAA | |
| Kynurenine SCHEMBL20702077 | 0.85 | KDM4E (0.57) | KDM4EHIF1ATDP1SLC1A3SLC1A2 | |
| L-Kynurenine SCHEMBL20875 | 0.85 | KDM4E (0.64) | KDM4EHIF1ATDP1SLC1A3SLC1A2 | |
| L-Kynurenine SCHEMBL13969610 | 0.85 | KDM4E (0.64) | KDM4EHIF1ATDP1SLC1A3SLC1A2 | |
| L-Kynurenine SCHEMBL29415716 | 0.85 | KDM4E (0.64) | KDM4EHIF1ATDP1SLC1A3SLC1A2 | |
| Kynurenine SCHEMBL2181581 | 0.85 | KDM4E (0.64) | KDM4EHIF1ATDP1SLC1A3SLC1A2 | |
| Kynurenine SCHEMBL20874 | 0.85 | KDM4E (0.64) | KDM4EHIF1ATDP1SLC1A3SLC1A2 | |
| Kynurenine SCHEMBL288988 | 0.85 | KDM4E (0.64) | KDM4EHIF1ATDP1SLC1A3SLC1A2 | |
| L-Kynurenine SCHEMBL288989 | 0.85 | KDM4E (0.64) | KDM4EHIF1ATDP1SLC1A3SLC1A2 | |
| Kynurenine SCHEMBL29349989 | 0.85 | KDM4E (0.64) | KDM4EHIF1ATDP1SLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0493506-A1 | CHIMERIC AMINO ACIDS AND PEPTIDES CONTAINING THESE ANALOGUES | GENENTECH, INC. (US) | 1992-07-08 | — | — | EP | disclosed |
| US-5120859-A | Anticoagulants | GENENTECH, INC. (US) | 1992-06-09 | — | — | US | disclosed |
| WO-1991004247-A1 | CHIMERIC AMINO ACIDS AND PEPTIDES CONTAINING THESE ANALOGUES | GENENTECH, INC. (US) | 1991-04-04 | — | — | WO | disclosed |