Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 4/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29677981 | 0.78 | PRKDC (0.55) | PRKDCMCL1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL1319784 | 0.78 | PRKDC (0.55) | PRKDCMCL1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL9635576 | 0.77 | CYP2D6 (0.38) | PRKDCTNKSCA1CA2LMNA | |
| SCHEMBL31673173 | 0.76 | CYP2A6 (0.52) | MAPTCYP2A6ADORA3ADORA2AADORA1 | |
| SCHEMBL4761517 | 0.76 | GPR35 (0.59) | CSNK2A2CSNK2BCSNK2A1ALDH1A1MAPT | |
| SCHEMBL6960093 | 0.76 | GPR35 (0.64) | ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL17843549 | 0.75 | CYP2A6 (0.37) | ALDH1A1MAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL6961386 | 0.73 | GPR35 (0.67) | MAPTLMNACYP3A4HPGD | |
| SCHEMBL16261665 | 0.73 | TSHR (0.50) | PRKDCMCL1CA1CA2ALDH1A1 | |
| SCHEMBL6956680 | 0.73 | TNKS (0.58) | TNKSCSNK2A2CSNK2BCSNK2A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082849-A | Antiinflammatory agents or antiallergens | AVENTIS PHARMACEUTICALS INC. | 1992-01-21 | — | — | US | disclosed |
| EP-0434827-A4 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1992-01-08 | — | — | EP | disclosed |
| EP-0434827-A1 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-07-03 | — | — | EP | disclosed |
| WO-1991001123-A2 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1991-02-07 | — | — | WO | disclosed |
| US-4977162-A | Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments | RORER PHARMACEUTICAL CORPORATION (US) | 1990-12-11 | — | — | US | disclosed |