Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9638812 | 0.86 | TSHR (0.35) | HPGDSMN1; SMN2TSHR | |
| SCHEMBL9638712 | 0.83 | TSHR (0.33) | HPGDSMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL9637695 | 0.81 | HPGD (0.30) | HPGDSMN1; SMN2 | |
| SCHEMBL9638375 | 0.74 | ALDH1A1 (0.45) | HPGDSMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL9637661 | 0.71 | ALDH1A1 (0.37) | HPGDSMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL9637680 | 0.65 | IKBKB (0.37) | PARP10NCOA1NCOA3HPGDSMN1; SMN2 | |
| SCHEMBL2059028 | 0.61 | HPGD (0.33) | HPGDSMN1; SMN2 | |
| SCHEMBL9638327 | 0.60 | — | — | |
| SCHEMBL30281403 | 0.59 | CA12 (0.49) | PARP10TSHRKMT2A | |
| SCHEMBL27805414 | 0.59 | PARP10 (0.43) | PARP10HPGDSMN1; SMN2TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0067436-B1 | DIAMINO ISOTHIAZOLE -1-OXIDES AND -1,1-DIOXIDES AS GASTRIC SECRETION INHIBITORS | MERCK & CO. INC. (US) | 1986-07-23 | — | — | EP | claimed |
| EP-0067436-A2 | Diamino isothiazole -1-oxides and -1,1-dioxides as gastric secretion inhibitors | MERCK & CO. INC. (US) | 1982-12-22 | — | — | EP | claimed |
| US-5171860-A | Diamino isothiazole-1-oxides and 1,1 dioxides as gastric secretion inhibitors | MERCK & CO., INC. (US) | 1992-12-15 | — | — | US | disclosed |
| EP-0067436-B1 | DIAMINO ISOTHIAZOLE -1-OXIDES AND -1,1-DIOXIDES AS GASTRIC SECRETION INHIBITORS | MERCK & CO. INC. (US) | 1986-07-23 | — | — | EP | disclosed |
| EP-0067436-A2 | Diamino isothiazole -1-oxides and -1,1-dioxides as gastric secretion inhibitors | MERCK & CO. INC. (US) | 1982-12-22 | — | — | EP | disclosed |