Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.78 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.75 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.75 |
| ▸ | PDE4A | P27815 | 11/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9638142 | 1.00 | KCNH2 (0.78) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9639129 | 0.94 | KCNH2 (0.69) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9639121 | 0.94 | KCNH2 (0.69) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9638207 | 0.91 | KCNH2 (0.69) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9638202 | 0.91 | KCNH2 (0.69) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9670657 | 0.90 | KCNH2 (0.84) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9670663 | 0.90 | KCNH2 (0.84) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9638810 | 0.88 | KCNH2 (0.81) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9639330 | 0.88 | KCNH2 (1.00) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9639332 | 0.88 | KCNH2 (1.00) | KCNH2PDE3BPDE3APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137885-A | THIADIAZINONES | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0492257-A1 | Thiadiazinone derivatives | MERCK PATENT GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |