Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 6/20 | 0.60 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL1332486 | 1.00 | — | — | |
| Bicarbonate SCHEMBL5403678 | 1.00 | CA4 (0.60) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL1929377 | 1.00 | — | — | |
| Bicarbonate SCHEMBL83 | 1.00 | — | — | |
| Bicarbonate SCHEMBL15321596 | 1.00 | CA4 (0.60) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL1332636 | 1.00 | — | — | |
| Bicarbonate SCHEMBL222994 | 1.00 | CA4 (0.60) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL10646323 | 1.00 | CA4 (0.60) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL8468228 | 0.94 | CA1 (0.56) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL9247593 | 0.94 | CA1 (0.56) | CA4FAHD1CA1MEN1LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207494-B | Highly soluble acetone-added pyrroloquinoline quinone salt | 三菱瓦斯化学株式会社 | 2020-01-21 | — | — | CN | disclosed |
| CN-1864707-A | Vaginal effervescence tablet of Ainsliaea fragrans and preparation method thereof | JIANGXI INST OF MATERIA MEDICA (CN) | 2006-11-22 | — | — | CN | disclosed |
| EP-0289223-B1 | REDUCTION OF CARBOXYLIC ESTERS | Takeda Chemical Industries, Ltd. (JP) | 1992-09-02 | — | — | EP | disclosed |
| EP-0289223-A1 | Reduction of carboxylic esters | Takeda Chemical Industries, Ltd. (JP) | 1988-11-02 | — | — | EP | disclosed |