Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9638585 | 1.00 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM4EGAAHTT | |
| SCHEMBL319880 | 0.63 | KMT2A (0.47) | ALDH1A1MAPTGAAHTTKMT2A | |
| Hydrochloric Acid SCHEMBL10827444 | 0.62 | KMT2A (0.46) | ALDH1A1MAPTGAAHTTKMT2A | |
| Iodide SCHEMBL29636313 | 0.62 | KMT2A (0.46) | ALDH1A1MAPTGAAHTTKMT2A | |
| SCHEMBL28806503 | 0.61 | MAPT (0.44) | ALDH1A1MAPTKDM4EGAAKMT2A | |
| SCHEMBL9638590 | 0.61 | RPS6KA2 (0.35) | ALDH1A1MAPTKDM4EGAAPOLB | |
| SCHEMBL4424169 | 0.61 | ALDH1A1 (0.49) | ALDH1A1MAPTGAAHTTKMT2A | |
| SCHEMBL17147756 | 0.60 | DUSP3 (0.47) | ALDH1A1 | |
| SCHEMBL1753885 | 0.59 | KMT2A (0.81) | ALDH1A1MAPTKDM4EGAAHTT | |
| SCHEMBL2615418 | 0.59 | KMT2A (0.81) | ALDH1A1MAPTKDM4EGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153218-A | N,N',N'-trisubstituted-bis-amino-3-methylene-2,4(3H,5H)-furandione inhibitors of acyl-CoA:cholesterol-acyl transferase | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |