Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8600948 | 0.82 | MAPT (0.46) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL7697934 | 0.78 | MAPT (0.59) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL2483154 | 0.77 | SMN1; SMN2 (0.46) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL1620480 | 0.75 | KMT2A (0.43) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL9438386 | 0.74 | MAPT (0.47) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL8568520 | 0.74 | BACE1 (0.56) | MAPTKMT2AMEN1LMNAGAA | |
| Fluoride SCHEMBL23234546 | 0.73 | NPC1 (0.43) | MAPTKMT2AMEN1LMNAGAA | |
| Hydrochloric Acid SCHEMBL28516416 | 0.73 | KMT2A (0.42) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL19897482 | 0.72 | MAPT (0.46) | MAPTKMT2ALMNAPKMNPC1 | |
| SCHEMBL7017905 | 0.72 | KMT2A (0.38) | KMT2AMEN1LMNAGAATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188007-B1 | PROCESS FOR THE PREPARATION OF 2-NITRO-3-AMINOPYRIDINE, AND THE N,N'-DI-(2-NITRO-3-PYRIDYL) UREA ITSELF OCCURRING AS AN INTERMEDIATE PRODUCT | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-08-19 | — | — | EP | disclosed |
| US-4952697-A | REACTING 3-AMINOPYRIDINE WITH PHOSGENE OR UREA, NITRATING AND HYDROLYSIS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-28 | — | — | US | disclosed |
| EP-0188007-A2 | Process for the preparation of 2-nitro-3-aminopyridine, and the N,N'-di-(2-nitro-3-pyridyl) urea itself occurring as an intermediate product | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-07-23 | — | — | EP | disclosed |