SCHEMBL9639485

SCHEMBL9639485

COC1=CC(=O)OC1C(OC(=O)[C@@H]1CCCN1)c1ccccc1Cl

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.36
CYP2D6 P10635 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C19 P33261 1/20 0.36
ELANE P08246 1/20 0.35
ROCK2 O75116 2/20 0.34
CYP2C9 P11712 1/20 0.34
TSHR P16473 1/20 0.34
KDM4E B2RXH2 1/20 0.33
IDO1 P14902 1/20 0.33
CTSC P53634 1/20 0.32
OPRL1 P41146 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL10393772 0.99 CYP3A4 (0.36) CYP3A4CYP2D6CYP1A2CYP2C19ELANE
Hydrochloric Acid SCHEMBL10394208 0.99 CYP3A4 (0.36) CYP3A4CYP2D6CYP1A2CYP2C19ELANE
SCHEMBL9640466 0.90 CYP3A4 (0.37) CYP3A4CYP2D6CYP1A2CYP2C19ELANE
SCHEMBL9640583 0.89 CCR4 (0.36) ROCK2KDM4E
SCHEMBL9640256 0.89 ROCK2 (0.35) ROCK2KDM4E
SCHEMBL9639322 0.89 CYP3A4 (0.36) CYP3A4CYP2D6CYP1A2CYP2C19ELANE
SCHEMBL9640340 0.89 CYP3A4 (0.36) CYP3A4CYP2D6CYP1A2CYP2C19ELANE
Bromide SCHEMBL10393937 0.88 CCR4 (0.36) ROCK2KDM4E
Bromide SCHEMBL10394124 0.88 ROCK2 (0.35) ROCK2KDM4E
Bromide SCHEMBL10393773 0.88 CYP3A4 (0.36) CYP3A4CYP2D6CYP1A2CYP2C19ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0349609-B1 AMINOACID ESTERS, PROCESS FOR THEIR MANUFACTURE AND THEIR USE Dr. Willmar Schwabe GmbH & Co. (DE) 1992-08-05 EP disclosed
EP-0349609-A1 AMINOACID ESTERS, PROCESS FOR THEIR MANUFACTURE AND THEIR USE Dr. Willmar Schwabe GmbH & Co. (DE) 1990-01-10 EP disclosed
WO-1989004310-A1 AMINOACID ESTERS, PROCESS FOR THEIR MANUFACTURE AND THEIR USE DR. WILLMAR SCHWABE GMBH & CO. (DE) 1989-05-18 WO disclosed