Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9642024 | 0.83 | CYP19A1 (0.56) | CYP19A1AOC3LMNAMAPTALOX12 | |
| SCHEMBL9641135 | 0.83 | CYP19A1 (0.56) | CYP19A1MEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9641597 | 0.81 | HRH1 (0.44) | CYP19A1 | |
| SCHEMBL9641594 | 0.81 | CYP19A1 (0.56) | SLC6A4CYP19A1AOC3 | |
| SCHEMBL9119464 | 0.79 | CYP19A1 (0.46) | CASRCYP19A1MEN1ALDH1A1LMNA | |
| SCHEMBL224560 | 0.79 | TAAR1 (0.51) | DRD2AOC3 | |
| SCHEMBL9119587 | 0.77 | CYP19A1 (0.49) | CYP19A1MEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9728311 | 0.76 | CYP19A1 (0.55) | CASRCYP19A1 | |
| SCHEMBL9121789 | 0.76 | CYP19A1 (0.57) | CYP19A1LMNAMAPTALOX12HTT | |
| SCHEMBL4379680 | 0.75 | KDM4E (0.49) | DRD2MEN1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0311447-B1 | AROMATASE INHIBITING 4(5)-IMIDAZOLES | ORION-YHTYMÀ OY (FI) | 1992-08-26 | — | — | EP | claimed |
| EP-0311447-A1 | Aromatase inhibiting 4(5)-imidazoles | ORION-YHTYMÀ OY (FI) | 1989-04-12 | — | — | EP | claimed |
| EP-0311447-B1 | AROMATASE INHIBITING 4(5)-IMIDAZOLES | ORION-YHTYMÀ OY (FI) | 1992-08-26 | — | — | EP | disclosed |
| US-5098923-A | Antiestrogens, anticarcinogenic agents or fungicides | FARMOS-YHTYMA OY (FI) | 1992-03-24 | — | — | US | disclosed |
| EP-0311447-A1 | Aromatase inhibiting 4(5)-imidazoles | ORION-YHTYMÀ OY (FI) | 1989-04-12 | — | — | EP | disclosed |