Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 2/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | VHL | P40337 | 1/20 | 0.41 |
| ▸ | ELOC | Q15369 | 1/20 | 0.41 |
| ▸ | ELOB | Q15370 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700006 | 0.84 | HPGD (0.50) | HPGDL3MBTL1AHRCMA1METAP1 | |
| SCHEMBL5535510 | 0.78 | HPGD (0.40) | HPGDL3MBTL1AHRCMA1METAP1 | |
| SCHEMBL30569555 | 0.76 | CMA1 (0.43) | HPGDL3MBTL1AHRCMA1METAP1 | |
| SCHEMBL29070094 | 0.76 | CMA1 (0.43) | HPGDL3MBTL1AHRCMA1METAP1 | |
| SCHEMBL9641861 | 0.76 | PARP1 (0.37) | PARP1PARP10TDP2HSD17B3MAPT | |
| SCHEMBL16250772 | 0.76 | ALDH1A1 (0.50) | HPGDMETAP1PARP1PARP10HSD17B3 | |
| SCHEMBL20734693 | 0.75 | BLM (0.32) | HPGD | |
| SCHEMBL28780269 | 0.74 | HPGD (0.61) | HPGDL3MBTL1HTR2AHTR2CHTR2B | |
| SCHEMBL7092813 | 0.72 | KDM4E (0.49) | HPGDL3MBTL1METAP1GAALMNA | |
| SCHEMBL11759541 | 0.71 | HPGD (0.63) | HPGDL3MBTL1METAP1VHLELOC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5147889-A | Antiinflammatory, analgesic | CIBA-GEIGY CORPORATION (US) | 1992-09-15 | — | — | US | disclosed |
| EP-0336886-B1 | THIO COMPOUNDS | CIBA-GEIGY AG (CH) | 1992-08-26 | — | — | EP | disclosed |
| US-5051421-A | Analgesics and antiinflammatory agents | CIBA-GEIGY CORPORATION (US) | 1991-09-24 | — | — | US | disclosed |
| EP-0336886-A1 | Thio compounds | CIBA-GEIGY AG (CH) | 1989-10-11 | — | — | EP | disclosed |
| US-4396621-A | ANALGESICS, ANTIIMFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-08-02 | — | — | US | disclosed |