Cyclopropane

Cyclopropane

SCHEMBL9640900

C1CC1.NCC(=O)OC(=O)CN

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GLRA1 P23415 1/20 0.37
SLC6A9 P48067 1/20 0.37
OR51E2 Q9H255 1/20 0.37
ALDH1A1 P00352 2/20 0.35
LMNA P02545 2/20 0.32
KDM4E B2RXH2 1/20 0.32
USP2 O75604 1/20 0.31
CYP1A2 P05177 1/20 0.31
TSHR P16473 1/20 0.31
BLM P54132 1/20 0.31
CACNA2D1 P54289 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
FFAR3 O14843 1/20 0.30
PEPD P12955 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL288431 0.90
Hydrogen Peroxide SCHEMBL4370693 0.87 GLRA1 (0.50) GLRA1SLC6A9OR51E2ALDH1A1LMNA
Hydrochloric Acid SCHEMBL27360124 0.87 GLRA1 (0.41) GLRA1SLC6A9OR51E2ALDH1A1LMNA
SCHEMBL6753492 0.87 GLRA1 (0.41) GLRA1SLC6A9OR51E2ALDH1A1LMNA
SCHEMBL6258848 0.87 GLRA1 (0.41) GLRA1SLC6A9OR51E2ALDH1A1LMNA
SCHEMBL10794891 0.87 GLRA1 (0.41) GLRA1SLC6A9OR51E2ALDH1A1LMNA
Ethylene SCHEMBL10887392 0.84 GLRA1 (0.39) GLRA1SLC6A9OR51E2ALDH1A1LMNA
SCHEMBL367247 0.81 ALDH1A1 (0.48) GLRA1SLC6A9OR51E2ALDH1A1LMNA
Glycine SCHEMBL27522318 0.81 GLRA1 (0.62) GLRA1SLC6A9OR51E2ALDH1A1LMNA
SCHEMBL5180477 0.79

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1038475-C Anticoccidial composition HOFFMANN LA ROCHE (CH) 1998-05-27 CN claimed
EP-0290998-B1 ANTICOCCIDIAL COMPOSITION F. HOFFMANN-LA ROCHE AG (CH) 1992-08-12 EP claimed
US-4839382-A SYNERGISTIC MIXTURE OF FRENOLICIN B AND AN IONOPHOROUS POLYETHER ANTIBIOTIC HOFFMANN-LA ROCHE INC. (US) 1989-06-13 US claimed
CN-1030527-A Anti-coccidiosis composition HOFFMANN LA ROCHE (CH) 1989-01-25 CN claimed
EP-0290998-A2 Anticoccidial composition F. HOFFMANN-LA ROCHE AG (CH) 1988-11-17 EP claimed
CN-1038475-C Anticoccidial composition HOFFMANN LA ROCHE (CH) 1998-05-27 CN disclosed
EP-0290998-B1 ANTICOCCIDIAL COMPOSITION F. HOFFMANN-LA ROCHE AG (CH) 1992-08-12 EP disclosed
US-5063219-A Anticoccidial composition HOFFMANN-LA ROCHE INC. (US) 1991-11-05 US disclosed
US-4996198-A Mixture of 2,4-diamino-5-(trisubstituted)benzyl-pyrimidine potentiated sulfonamide antibiotic with an ionophorous polyether HOFFMANN-LA ROCHE INC. (US) 1991-02-26 US disclosed
US-4839382-A SYNERGISTIC MIXTURE OF FRENOLICIN B AND AN IONOPHOROUS POLYETHER ANTIBIOTIC HOFFMANN-LA ROCHE INC. (US) 1989-06-13 US disclosed
CN-1030527-A Anti-coccidiosis composition HOFFMANN LA ROCHE (CH) 1989-01-25 CN disclosed
EP-0290998-A2 Anticoccidial composition F. HOFFMANN-LA ROCHE AG (CH) 1988-11-17 EP disclosed