Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2296887 | 0.85 | MEN1 (0.41) | CYP2D6CYP1A2GSK3BKMT2AMAOB | |
| SCHEMBL2294966 | 0.85 | MEN1 (0.41) | CYP2D6CYP1A2GSK3BKMT2AMAOB | |
| SCHEMBL2295159 | 0.85 | MDM2 (0.41) | TSHRPOLBSRD5A1RIPK1KDM4E | |
| SCHEMBL2297295 | 0.85 | MDM2 (0.47) | TSHRCYP2D6CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL2295639 | 0.85 | MDM2 (0.41) | TSHRPOLBSRD5A1RIPK1KDM4E | |
| SCHEMBL2293124 | 0.85 | MDM2 (0.47) | TSHRCYP2D6CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL9640858 | 0.83 | MDM2 (0.49) | TSHRSLC6A3RIPK1ALDH1A1KDM4E | |
| SCHEMBL2295427 | 0.83 | RIPK1 (0.38) | KMT2ARIPK1ALDH1A1HTR1ACYP19A1 | |
| SCHEMBL2297588 | 0.83 | RIPK1 (0.38) | KMT2ARIPK1ALDH1A1HTR1ACYP19A1 | |
| SCHEMBL2293375 | 0.83 | TP53 (0.46) | KMT2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290122-B1 | MORPHOLINE DERIVATIVES AND THEIR USE | BEECHAM GROUP PLC (GB) | 1992-12-23 | — | — | EP | disclosed |
| US-5082840-A | Animal growth regulators | BEECHAM GROUP P.L.C. (GB) | 1992-01-21 | — | — | US | disclosed |
| US-4914202-A | FOR IMPROVING FEED EFFICIENCY IN LIVESTOCK | BEECHAM GROUP P.L.C. (GB) | 1990-04-03 | — | — | US | disclosed |
| EP-0290122-A1 | Morpholine derivatives and their use | BEECHAM GROUP PLC (GB) | 1988-11-09 | — | — | EP | disclosed |