⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4641763 | 0.75 | — | — | |
| SCHEMBL1401727 | 0.72 | KDM6B (0.43) | — | |
| SCHEMBL4018720 | 0.72 | KDM6B (0.43) | — | |
| SCHEMBL29180353 | 0.71 | — | — | |
| SCHEMBL11517514 | 0.71 | — | — | |
| SCHEMBL28325720 | 0.69 | — | — | |
| SCHEMBL156391 | 0.69 | — | — | |
| SCHEMBL8499931 | 0.67 | — | — | |
| SCHEMBL743846 | 0.67 | — | — | |
| SCHEMBL19286875 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111793060-A | NLRP3 modulators | 先天肿瘤免疫公司 | 2020-10-20 | — | — | CN | disclosed |
| EP-1871772-B1 | QUINOLINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE INC (US) | 2014-09-10 | — | — | EP | disclosed |
| US-8003664-B2 | Indazole-carboxamide compounds | THERAVANCE, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-7875629-B2 | minimal side effects, improved selectivity, potency, pharmacokinetics, and/or duration of action; 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-[3-(4-methanesulfonylpiperazine-1-sulfonyl)propyl]-8-azabicyclo[3.2.1]oct-3-yl}amide; reduced motility of the gastrointestinal tract | THERAVANCE, INC. (US) | 2011-01-25 | — | — | US | disclosed |
| US-7851467-B2 | Carbamate compounds as 5-HT4 receptor agonists | THERAVANCE, INC. (US) | 2010-12-14 | — | — | US | disclosed |
| US-20100292223-A1 | INDAZOLE-CARBOXAMIDE COMPOUNDS | THERAVANCE, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| US-7786136-B2 | Indazole-carboxamide compounds | THERAVANCE, INC. (US) | 2010-08-31 | — | — | US | disclosed |
| EP-1831211-B1 | INDAZOLE-CARBOXAMIDE COMPOUNDS | THERAVANCE INC (US) | 2010-06-02 | — | — | EP | disclosed |
| EP-1960396-B1 | CARBAMATE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE INC (US) | 2009-11-11 | — | — | EP | disclosed |
| EP-1807422-B1 | 5-HT4 RECEPTOR AGONIST COMPOUNDS | THERAVANCE INC (US) | 2009-09-02 | — | — | EP | disclosed |
| US-20060135764-A1 | Indazole-carboxamide compounds | THERAVANCE, INC. | 2006-06-22 | — | — | US | disclosed |
| WO-2006052640-A1 | 5-HT4 RECEPTOR AGONIST COMPOUNDS | THERAVANCE, INC. (US) | 2006-05-18 | — | — | WO | disclosed |
| WO-2006052889-A2 | QUINOLINONE-CARBOXAMIDE COMPOUNDS | THERAVANCE, INC. (US) | 2006-05-18 | — | — | WO | disclosed |
| US-20060100236-A1 | For therapy of disorder of reduced motility of gastrointestinal tract, chronic constipation, functional dyspepsia, delayed gastric emptying, gastroesophageal reflux disease, gastroparesis, diabetic and iodiopathic gastropathy, post-operative ileus, intestinal pseudo-obstruction, irritable bowel syndrome | THERAVANCE, INC. (US) | 2006-05-11 | — | — | US | disclosed |
| US-20060100426-A1 | Quinolinone-carboxamide compounds | THERAVANCE, INC. | 2006-05-11 | — | — | US | disclosed |
| US-5886175-A | TETRACYCLINE ANTIBIOTICS | AMERICAN CYANAMID COMPANY (US) | 1999-03-23 | — | — | US | disclosed |
| US-5512553-A | PREVENTING OR TREATING BACTERIAL INFECTIONS | AMERICAN CYANAMID COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| US-5495018-A | ANTIBIOTIC INTERMEDIATES | AMERICAN CYANAMID COMPANY (US) | 1996-02-27 | — | — | US | disclosed |
| US-5430162-A | Tetracycline antibiotics | AMERICAN CYANAMID COMPANY (US) | 1995-07-04 | — | — | US | disclosed |
| EP-0582810-A1 | Novel 7-(substituted)-8-(substituted)-9-(substituted amino)-6-demethyl-6-deoxyetracyclines as antibiotic agents | AMERICAN CYANAMID COMPANY (US) | 1994-02-16 | — | — | EP | disclosed |