Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 2/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.36 |
| ▸ | RELA | Q04206 | 3/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 2/20 | 0.35 |
| ▸ | FNTB | P49356 | 2/20 | 0.35 |
| ▸ | POLA1 | P09884 | 1/20 | 0.35 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697426 | 1.00 | HMGCR (0.42) | HMGCRPTPN1MEN1KMT2AUSP2 | |
| SCHEMBL10697421 | 0.89 | HMGCR (0.38) | HMGCRPTPN1MEN1KMT2AUSP2 | |
| SCHEMBL9766762 | 0.88 | MEN1 (0.53) | HMGCRPTPN1MEN1KMT2AUSP2 | |
| SCHEMBL10588575 | 0.85 | MEN1 (0.41) | HMGCRMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL11410370 | 0.85 | MEN1 (0.49) | MEN1KMT2AUSP2ALDH1A1MAPT | |
| SCHEMBL10424791 | 0.85 | MEN1 (0.49) | MEN1KMT2AUSP2ALDH1A1MAPT | |
| SCHEMBL10425134 | 0.85 | MEN1 (0.49) | MEN1KMT2AUSP2ALDH1A1MAPT | |
| SCHEMBL9769598 | 0.81 | USP2 (0.40) | PTPN1USP2ALDH1A1MAPTALOX15 | |
| SCHEMBL9769618 | 0.81 | USP2 (0.40) | PTPN1USP2ALDH1A1MAPTALOX15 | |
| SCHEMBL9644245 | 0.79 | HMGCR (0.46) | HMGCRPTPN1NR1H4PTGESNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276823-B1 | 14,15-SUBSTITUTED LANOSTEROLS AND THEIR USE AS HYPOCHOLESTEROLEMIC AGENTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-09-23 | — | — | EP | disclosed |
| US-5041432-A | Enzyme inhibitors | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-08-20 | — | — | US | disclosed |
| US-5034548-A | Enzyme inhibitors for reducing serum cholesterol | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-07-23 | — | — | US | disclosed |
| EP-0276823-A2 | 14,15-Substituted lanosterols and their use as hypocholesterolemic agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1988-08-03 | — | — | EP | disclosed |