Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 3/20 | 0.37 |
| ▸ | CDC25A | P30304 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 5/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 2/20 | 0.35 |
| ▸ | FNTB | P49356 | 2/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9769618 | 1.00 | USP2 (0.40) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL6405712 | 0.86 | CDC25B (0.49) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL6409795 | 0.84 | USP2 (0.41) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL7701847 | 0.83 | NR1H4 (0.35) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL7701851 | 0.83 | NR1H4 (0.35) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL9644062 | 0.81 | MAPT (0.45) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL9644065 | 0.81 | MAPT (0.45) | USP2ALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL10697426 | 0.81 | HMGCR (0.42) | USP2ALDH1A1MAPTALOX15CDC25B | |
| SCHEMBL9643863 | 0.81 | HMGCR (0.42) | USP2ALDH1A1MAPTALOX15CDC25B | |
| SCHEMBL6405681 | 0.79 | USP2 (0.38) | USP2ALDH1A1CYP3A4MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041432-A | Enzyme inhibitors | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-08-20 | — | — | US | disclosed |
| US-5034548-A | Enzyme inhibitors for reducing serum cholesterol | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-07-23 | — | — | US | disclosed |
| EP-0276823-A2 | 14,15-Substituted lanosterols and their use as hypocholesterolemic agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1988-08-03 | — | — | EP | disclosed |