Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 18/20 | 0.57 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9645457 | 0.94 | ALOX5 (0.55) | ALOX5 | |
| SCHEMBL9645354 | 0.85 | ALOX5 (0.69) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL9647049 | 0.82 | ALOX5 (0.56) | ALOX5CRBN | |
| SCHEMBL9644485 | 0.80 | ALOX5 (0.74) | ALOX5 | |
| SCHEMBL9645657 | 0.77 | ALOX5 (0.80) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL11015392 | 0.77 | ALOX5 (0.55) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL10512680 | 0.77 | ALOX5 (0.73) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL10878292 | 0.75 | ALOX5 (0.67) | ALOX5DDB1CRBNG6PDALOX15 | |
| SCHEMBL6597563 | 0.75 | USP2 (0.56) | — | |
| SCHEMBL9645256 | 0.73 | ALOX5 (1.00) | ALOX5G6PDALOX15ALOX12PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |