Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 5/20 | 0.36 |
| ▸ | GSK3B | P49841 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.35 |
| ▸ | G6PD | P11413 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10514802 | 0.78 | CFTR (0.32) | GSK3BGAAALOX12MEN1RAB9A | |
| SCHEMBL10515777 | 0.67 | KAT2B (0.40) | GSK3AGSK3BGAAG6PDALOX15 | |
| SCHEMBL9644474 | 0.67 | GSK3A (0.41) | GSK3AGSK3BGAAALOX5G6PD | |
| SCHEMBL9644558 | 0.67 | ALOX5 (0.38) | GSK3AGSK3BGAAALOX5G6PD | |
| SCHEMBL10514307 | 0.66 | GAA (0.36) | GSK3AGSK3BGAAALOX5G6PD | |
| Ammonia Solution, Strong SCHEMBL1065028 | 0.65 | CFTR (0.33) | GSK3AGSK3BGAA | |
| SCHEMBL4093751 | 0.65 | ALOX5 (0.43) | GSK3AGSK3BGAAALOX5G6PD | |
| SCHEMBL9646990 | 0.63 | ELANE (0.37) | GSK3AGSK3BGAAALOX5G6PD | |
| SCHEMBL2828339 | 0.63 | ALOX5 (0.48) | GSK3AGSK3BGAAALOX5G6PD | |
| SCHEMBL9644526 | 0.62 | KMT2A (0.39) | GSK3AGSK3BGAAALOX5G6PD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |