Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 18/20 | 1.00 |
| ▸ | G6PD | P11413 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10947701 | 0.90 | ALOX5 (0.82) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL9645270 | 0.83 | ALOX5 (0.71) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL9644532 | 0.83 | ALOX5 (1.00) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL9644528 | 0.81 | ALOX5 (1.00) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL9647006 | 0.81 | ALOX5 (0.68) | ALOX5ALDH1A1POLBGAAMAPT | |
| SCHEMBL9644476 | 0.81 | ALOX5 (1.00) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL9645398 | 0.81 | ALOX5 (1.00) | ALOX5ALDH1A1MAPT | |
| SCHEMBL9647122 | 0.80 | ALOX5 (0.70) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL1274602 | 0.80 | ALOX5 (1.00) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL9647020 | 0.79 | ALOX5 (1.00) | ALOX5G6PDALOX15ALOX12PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |