Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.90 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.90 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.90 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.90 |
| ▸ | ADORA2B | P29275 | 9/20 | 0.90 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9430425 | 0.99 | PDE4A (0.92) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9430830 | 0.95 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9430292 | 0.94 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9431257 | 0.91 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL3990422 | 0.91 | ADORA2B (0.94) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9430589 | 0.90 | PDE4A (0.90) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9430034 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL21381259 | 0.88 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL7738354 | 0.88 | ADORA2B (1.00) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL3842077 | 0.88 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269841-B1 | 1-HYDROXYALKYL XANTHINES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1992-11-11 | — | — | EP | claimed |
| EP-0269841-A1 | 1-Hydroxyalkyl xanthines, processes for their preparation and medicaments containing them | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1988-06-08 | — | — | EP | claimed |
| EP-0269841-B1 | 1-HYDROXYALKYL XANTHINES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1992-11-11 | — | — | EP | disclosed |
| US-5053433-A | Photodiesterase inhibitor | SOCIETE ANONYME DITE: L'OREAL (FR) | 1991-10-01 | — | — | US | disclosed |
| EP-0269841-A1 | 1-Hydroxyalkyl xanthines, processes for their preparation and medicaments containing them | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1988-06-08 | — | — | EP | disclosed |