Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28921358 | 0.80 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL29077661 | 0.76 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL21475875 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL31315689 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL24754579 | 0.74 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL11762270 | 0.73 | SLC6A2 (0.37) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL25101248 | 0.72 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL5884242 | 0.71 | HSD17B10 (0.50) | HPGDHSD17B10TDP1KMT2AMAPT | |
| SCHEMBL7898823 | 0.70 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL1602967 | 0.69 | KDM4E (0.59) | KDM4EALDH1A1HPGDHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0304322-B1 | 1-SUBSTITUTED ALKYL-2-OXO-1,2-DIHYDROQUINOXALINE DERIVATIVES | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1992-12-02 | — | — | EP | disclosed |
| US-4870171-A | HYPOTENSIVE | TOYO JOZO KABUSHIKI KAISHA (JP) | 1989-09-26 | — | — | US | disclosed |
| EP-0304322-A1 | 1-Substituted alkyl-2-oxo-1,2-dihydroquinoxaline derivatives | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1989-02-22 | — | — | EP | disclosed |