Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 17/20 | 0.81 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.76 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.76 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.68 |
| ▸ | DRD4 | P21917 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6359486 | 0.99 | OPRK1 (0.79) | OPRK1OPRM1CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL5629280 | 0.99 | OPRK1 (0.79) | OPRK1OPRM1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2683751 | 0.90 | OPRK1 (0.82) | OPRK1OPRM1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8221866 | 0.89 | OPRK1 (1.00) | OPRK1OPRM1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8221863 | 0.89 | OPRK1 (1.00) | OPRK1OPRM1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10417791 | 0.88 | OPRK1 (1.00) | OPRK1OPRM1CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL5629721 | 0.88 | OPRK1 (0.98) | OPRK1OPRM1CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL5629714 | 0.88 | OPRK1 (0.98) | OPRK1OPRM1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10416654 | 0.88 | OPRK1 (1.00) | OPRK1OPRM1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4545382 | 0.87 | OPRK1 (1.00) | OPRK1OPRM1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116842-A | Analgesics | GLAXO GROUP LIMITED (GB) | 1992-05-26 | — | — | US | disclosed |
| EP-0398720-A2 | Piperazine derivatives | GLAXO GROUP LIMITED (GB) | 1990-11-22 | — | — | EP | disclosed |