⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2419664 | 0.76 | — | — | |
| SCHEMBL10996644 | 0.73 | TSHR (0.31) | — | |
| SCHEMBL4912204 | 0.73 | — | — | |
| SCHEMBL4911927 | 0.70 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL2067724 | 0.68 | — | — | |
| SCHEMBL4575 | 0.67 | — | — | |
| SCHEMBL1609639 | 0.67 | — | — | |
| SCHEMBL1609662 | 0.67 | — | — | |
| SCHEMBL1337870 | 0.67 | — | — | |
| SCHEMBL271888 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9163035-B2 | Melonine bisindole compounds, pharmaceutical compositions, preparation method and use thereof | KUNMING INSTITUTE OF BOTANY, THE CHINESE ACADEMY OF SCIENCES (CN) | 2015-10-20 | — | — | US | disclosed |
| US-8735387-B2 | Oxazolopyrimidines as Edg-1 receptor agonists | SANOFI (FR) | 2014-05-27 | — | — | US | disclosed |
| US-20120291159-A1 | Azoline Compounds for Combating Invertebrate Pests | BASF SE (DE) | 2012-11-15 | — | — | US | disclosed |
| US-20120283284-A1 | MELONINE BISINDOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHOD AND USE THEREOF | KUNMING INSTITUTE OF BOTANY, THE CHINESE ACADEMY OF SCIENCES (CN) | 2012-11-08 | — | — | US | disclosed |
| US-20110190490-A1 | OXAZOLOPYRIMIDINES AS EDG-1 RECEPTOR AGONISTS | SANOFI-AVENTIS (FR) | 2011-08-04 | — | — | US | disclosed |
| WO-2011073444-A2 | AZOLINE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS | BASF SE (DE) | 2011-06-23 | — | — | WO | disclosed |
| US-20110021517-A1 | ANTITUMOR COMBINATION COMPRISING A MORPHOLINYL ANTHRACYCLINE DERIVATIVE AND DEMETHYLATING AGENTS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-01-27 | — | — | US | disclosed |
| EP-2257310-A2 | ANTITUMOR COMBINATION COMPRISING A MORPHOLINYL ANTHRACYCLINE DERIVATIVE AND DEMETHYLATING AGENTS | Nerviano Medical Sciences S.r.l. (IT) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009106549-A2 | ANTITUMOR COMBINATION COMPRISING A MORPHOLINYL ANTHRACYCLINE DERIVATIVE AND DEMETHYLATING AGENTS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-09-03 | — | — | WO | disclosed |
| US-20080200475-A1 | 4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors | PFIZER INC. | 2008-08-21 | — | — | US | disclosed |
| EP-1866317-A1 | 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006103555-A1 | 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-10-05 | — | — | WO | disclosed |
| EP-1605951-A1 | COMBINED THERAPY COMPRISING NEMORUBICIN AND A CYCLOOXYGENASE-2-INHIBITOR | Pharmacia Italia S.p.A. (IT) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004082689-A1 | COMBINED THERAPY COMPRISING NEMORUBICIN AND A CYCLOOXYGENASE-2-INHIBITOR | PHARMACIA ITALIA SPA (IT) | 2004-09-30 | — | — | WO | disclosed |
| US-4552879-A | BACTERICIDES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-11-12 | — | — | US | disclosed |
| US-4399134-A | BACTERICIDES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1983-08-16 | — | — | US | disclosed |