Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 17/20 | 0.55 |
| ▸ | AGTR2 | P50052 | 17/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9654363 | 0.96 | AGTR1 (0.57) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9654052 | 0.91 | AGTR1 (0.60) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9653124 | 0.87 | AGTR1 (0.62) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9589902 | 0.84 | AGTR1 (0.63) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL9591558 | 0.84 | AGTR1 (0.75) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9592385 | 0.84 | AGTR1 (0.76) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9655032 | 0.83 | AGTR1 (0.61) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL9681034 | 0.82 | AGTR1 (0.74) | AGTR1AGTR2 | |
| Hydrochloric Acid SCHEMBL9591473 | 0.82 | AGTR1 (0.75) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9590611 | 0.82 | AGTR1 (0.76) | AGTR1AGTR2PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992014468-A1 | PSORIASIS TREATMENT | ABBOTT LABORATORIES (US) | 1992-09-03 | — | — | WO | disclosed |
| US-5104877-A | Psoriasis treatment | ABBOTT LABORATORIES (US) | 1992-04-14 | — | — | US | disclosed |