SCHEMBL9653308

SCHEMBL9653308

CC(C)(F)C(=O)/C(C#N)=C(\O)c1ccc(Cl)cc1[N+](=O)[O-]

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
VCAM1 P19320 1/20 0.43
HPGD P15428 4/20 0.42
CYP1A2 P05177 2/20 0.42
CYP3A4 P08684 2/20 0.42
CYP2C19 P33261 2/20 0.42
FLT1 P17948 2/20 0.41
FLT4 P35916 2/20 0.41
KDR P35968 2/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.40
POLB P06746 1/20 0.39
APP P05067 1/20 0.39
LMNA P02545 1/20 0.38
MAPK1 P28482 1/20 0.38
GABRA1 P14867 3/20 0.38
GABRG2 P18507 3/20 0.38
GABRB3 P28472 3/20 0.38
GABRB2 P47870 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9653312 1.00 VCAM1 (0.43) VCAM1HPGDCYP1A2CYP3A4CYP2C19
SCHEMBL9653757 0.93 VCAM1 (0.43) VCAM1HPGDCYP1A2CYP3A4CYP2C19
SCHEMBL9653763 0.93 VCAM1 (0.43) VCAM1HPGDCYP1A2CYP3A4CYP2C19
SCHEMBL9652133 0.92 VCAM1 (0.44) VCAM1HPGDCYP1A2CYP3A4CYP2C19
SCHEMBL9653706 0.91 VCAM1 (0.45) VCAM1HPGDCYP1A2CYP3A4CYP2C19
SCHEMBL9653701 0.91 VCAM1 (0.45) VCAM1HPGDCYP1A2CYP3A4CYP2C19
SCHEMBL9651938 0.91 VCAM1 (0.45) VCAM1HPGDCYP1A2CYP3A4CYP2C19
SCHEMBL9651943 0.91 VCAM1 (0.45) VCAM1HPGDCYP1A2CYP3A4CYP2C19
SCHEMBL9650710 0.91 VCAM1 (0.45) VCAM1HPGDCYP1A2CYP3A4CYP2C19
SCHEMBL9650708 0.91 VCAM1 (0.45) VCAM1HPGDCYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0213892-B1 HERBICIDALLY ACTIVE ENOLS ROHM AND HAAS COMPANY (US) 1992-03-25 EP disclosed
US-4781750-A Herbicidally active enols ROHM AND HAAS COMPANY (US) 1988-11-01 US disclosed
EP-0213892-A2 Herbicidally active enols ROHM AND HAAS COMPANY (US) 1987-03-11 EP disclosed