Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CTSS | P25774 | 3/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162182 | 0.79 | KMT2A (0.54) | KMT2ACTSSCTSKCTSLCTSB | |
| SCHEMBL6624362 | 0.78 | KMT2A (0.53) | KMT2ACTSSCTSKCTSLCTSB | |
| SCHEMBL4900321 | 0.77 | KMT2A (0.67) | KMT2ACTSSCTSKCTSLCTSB | |
| SCHEMBL5408063 | 0.77 | KMT2A (0.67) | KMT2ACTSSCTSKCTSLCTSB | |
| SCHEMBL6165560 | 0.76 | KMT2A (0.60) | KMT2ACTSSCTSKCTSLCTSB | |
| SCHEMBL6350465 | 0.76 | KMT2A (0.66) | KMT2ACTSSCTSKCTSLCTSB | |
| SCHEMBL2374657 | 0.76 | SCN9A (0.61) | KMT2ACTSSCTSKCTSLCTSB | |
| SCHEMBL2374682 | 0.76 | SCN9A (0.61) | KMT2ACTSSCTSKCTSLCTSB | |
| SCHEMBL15645213 | 0.76 | CTSS (0.52) | KMT2ACTSSCTSKCTSLCTSB | |
| SCHEMBL13340029 | 0.76 | KMT2A (0.52) | KMT2ACTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318091-B1 | RESOLVED AMINO PYRROLIDINE NEUROPROTECTIVE AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1992-12-09 | — | — | EP | disclosed |
| US-4863953-A | [3R]-3-amino-1-hydroxy pyrrolidin-2-one and its use as a neuroprotective agent | MERCK & CO., INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0318091-A2 | Resolved amino pyrrolidine neuroprotective agents | MERCK SHARP & DOHME LTD. (GB) | 1989-05-31 | — | — | EP | disclosed |