Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | CCKAR | P32238 | 2/20 | 0.37 |
| ▸ | CCKBR | P32239 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9655794 | 1.00 | MCL1 (0.48) | MCL1MAPTSLC9A1MEN1NPC1 | |
| SCHEMBL16756076 | 0.75 | MCL1 (0.64) | MCL1MAPTSLC9A1MEN1NPC1 | |
| SCHEMBL10390907 | 0.74 | MAPT (0.53) | MAPTMEN1KMT2A | |
| SCHEMBL10390906 | 0.74 | MAPT (0.53) | MAPTMEN1KMT2A | |
| SCHEMBL9655818 | 0.74 | RAB9A (0.47) | MAPTMEN1NPC1RAB9AKMT2A | |
| SCHEMBL9654204 | 0.74 | PPARD (0.51) | SLC9A1RAB9A | |
| SCHEMBL9654193 | 0.74 | PPARD (0.51) | SLC9A1RAB9A | |
| SCHEMBL9655837 | 0.74 | RAB9A (0.47) | MAPTMEN1NPC1RAB9AKMT2A | |
| Fumaric Acid SCHEMBL9656759 | 0.73 | CYP1B1 (0.53) | MAPTMEN1KMT2A | |
| Maleic Acid SCHEMBL9656753 | 0.73 | CYP1B1 (0.53) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084474-A | Antagonist of 5-hydroxytryptamine receptors on nerves and useful for treatment of psychotic disorders, anxiety, and nausea and vomiting, compounds of imidazole | GLAXO GROUP LIMITED (GB) | 1992-01-28 | — | — | US | disclosed |
| US-5019586-A | 5-Hydroxytryptamine Receptor Antagonists | GLAXO GROUP LIMITED | 1991-05-28 | — | — | US | disclosed |
| US-4918080-A | ANXIOLYTIC AGENTS, ANTIEMETICS | GLAXO GROUP LIMITED (GB) | 1990-04-17 | — | — | US | disclosed |
| EP-0291172-A1 | Ketone derivatives | GLAXO GROUP LIMITED (GB) | 1988-11-17 | — | — | EP | disclosed |