Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10417102 | 0.85 | CCNA2 (0.40) | ADRA2AADRA2BADRA2CCDK5CDK5R1 | |
| SCHEMBL2085329 | 0.78 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CCDK5CDK5R1 | |
| SCHEMBL9654439 | 0.74 | MAPT (0.41) | CDK5CDK5R1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL25060963 | 0.73 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CCDK5CDK5R1 | |
| SCHEMBL20877646 | 0.73 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CCDK5CDK5R1 | |
| SCHEMBL20877621 | 0.73 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CCDK5CDK5R1 | |
| SCHEMBL19817529 | 0.73 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CCDK5CDK5R1 | |
| SCHEMBL31003113 | 0.71 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CCDK5CDK5R1 | |
| SCHEMBL4170763 | 0.71 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CCDK5CDK5R1 | |
| SCHEMBL30437840 | 0.69 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAHPGDALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4975431-A | Certain anti-inflammatory cyclohepta[b]pyridines and analogs thereof | JOHN WYETH & BROTHER LIMITED (GB) | 1990-12-04 | — | — | US | claimed |
| US-5112832-A | Nonsteroid antiinflammatory agents | JOHN WYETH & BROTHER LIMITED (GB) | 1992-05-12 | — | — | US | disclosed |
| US-5026854-A | Bromination, cyclization | JOHN WYETH & BROTHER LIMITED (GB) | 1991-06-25 | — | — | US | disclosed |
| US-4975431-A | Certain anti-inflammatory cyclohepta[b]pyridines and analogs thereof | JOHN WYETH & BROTHER LIMITED (GB) | 1990-12-04 | — | — | US | disclosed |