SCHEMBL9656169

SCHEMBL9656169

Cc1[nH]cnc1C=CC(=O)c1cccc2c(F)cccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.38
MAPK1 P28482 3/20 0.38
ALDH1A1 P00352 2/20 0.38
LMNA P02545 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
TP53 P04637 1/20 0.38
HPGD P15428 1/20 0.38
KMT2A Q03164 1/20 0.38
MAOB P27338 3/20 0.36
PARP1 P09874 2/20 0.36
CYP1B1 Q16678 3/20 0.35
CYP1A1 P04798 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP2D6 P10635 2/20 0.35
CYP3A4 P08684 1/20 0.35
MITF O75030 1/20 0.34
MDM2 Q00987 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
PTGS2 P35354 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9656161 1.00 MAPT (0.38) MAPTMAPK1ALDH1A1LMNAKDM4E
SCHEMBL10390906 0.85 MAPT (0.53) MAPTMAPK1ALDH1A1LMNAKDM4E
SCHEMBL10390907 0.85 MAPT (0.53) MAPTMAPK1ALDH1A1LMNAKDM4E
Fumaric Acid SCHEMBL9655909 0.81 ALDH1A1 (0.52) MAPTMAPK1ALDH1A1LMNAKDM4E
Maleic Acid SCHEMBL9655896 0.81 ALDH1A1 (0.52) MAPTMAPK1ALDH1A1LMNAKDM4E
SCHEMBL9656633 0.78 MAPT (0.41) MAPTMAPK1ALDH1A1LMNAKDM4E
SCHEMBL9656629 0.78 MAPT (0.41) MAPTMAPK1ALDH1A1LMNAKDM4E
SCHEMBL9656155 0.75 ABCG2 (0.58) MAPTALDH1A1LMNAKDM4EMEN1
SCHEMBL9656148 0.75 ABCG2 (0.58) MAPTALDH1A1LMNAKDM4EMEN1
SCHEMBL9654266 0.75 NPC1 (0.46) MAPTALDH1A1MEN1TP53HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0291172-B1 KETONE DERIVATIVES GLAXO GROUP LIMITED (GB) 1992-11-19 EP disclosed
US-5084474-A Antagonist of 5-hydroxytryptamine receptors on nerves and useful for treatment of psychotic disorders, anxiety, and nausea and vomiting, compounds of imidazole GLAXO GROUP LIMITED (GB) 1992-01-28 US disclosed
US-5019586-A 5-Hydroxytryptamine Receptor Antagonists GLAXO GROUP LIMITED 1991-05-28 US disclosed
US-4918080-A ANXIOLYTIC AGENTS, ANTIEMETICS GLAXO GROUP LIMITED (GB) 1990-04-17 US disclosed
EP-0291172-A1 Ketone derivatives GLAXO GROUP LIMITED (GB) 1988-11-17 EP disclosed