Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 12/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 10/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.35 |
| ▸ | GRB2 | P62993 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2500137 | 1.00 | DPP4 (0.35) | DPP4DPP7DPP8DPP9GRB2 | |
| SCHEMBL15765659 | 0.85 | — | — | |
| SCHEMBL4104050 | 0.85 | — | — | |
| SCHEMBL4103974 | 0.85 | — | — | |
| Trifluoroacetic Acid SCHEMBL2496872 | 0.85 | DPP8 (0.38) | DPP4DPP7DPP8DPP9GRB2 | |
| Trifluoroacetic Acid SCHEMBL2496719 | 0.81 | DPP4 (0.34) | DPP4DPP7DPP8DPP9GRB2 | |
| Trifluoroacetic Acid SCHEMBL2494882 | 0.81 | SLC7A5 (0.48) | DPP4DPP7DPP8DPP9SLC1A1 | |
| Trifluoroacetic Acid SCHEMBL2493179 | 0.81 | DPP8 (0.36) | DPP4DPP7DPP8DPP9GRB2 | |
| Trifluoroacetic Acid SCHEMBL2496044 | 0.79 | DPP4 (0.41) | DPP4DPP7DPP8DPP9KCNH2 | |
| Trifluoroacetic Acid SCHEMBL2493278 | 0.79 | ALOX15 (0.48) | DPP4DPP7DPP8DPP9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5089491-A | Active against both gram-negative and gram-positive bacteria | EISAI CO., LTD. (JP) | 1992-02-18 | — | — | US | disclosed |
| EP-0264091-B1 | 3-PROPENYLCEPHEM DERIVATIVE, PREPARATION THEREOF, CHEMICAL INTERMEDIATES THEREIN, PHARMACEUTICAL COMPOSITION AND USE | Eisai Co., Ltd. (JP) | 1992-02-05 | — | — | EP | disclosed |
| US-5066812-A | Chemical intermediates for bactericides | EISAI CO., LTD. (JP) | 1991-11-19 | — | — | US | disclosed |
| US-5006649-A | Bactericides | EISAI, CO. (JP) | 1991-04-09 | — | — | US | disclosed |
| US-4921850-A | GRAMNEGATIVE AND GRAMPOSITIVE BACTERICIDE | EISAI CO., LTD. (JP) | 1990-05-01 | — | — | US | disclosed |
| EP-0264091-A2 | 3-Propenylcephem derivative, preparation thereof, chemical intermediates therein, pharmaceutical composition and use | Eisai Co., Ltd. (JP) | 1988-04-20 | — | — | EP | disclosed |