Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | ERN1 | O75460 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.40 |
| ▸ | TUBB | P07437 | 2/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657079 | 0.85 | HIF1A (0.50) | MAPTHSD17B10ALDH1A1ERN1HIF1A | |
| SCHEMBL2022420 | 0.83 | MAPT (0.49) | MAPTHSD17B10ALDH1A1ERN1HIF1A | |
| SCHEMBL2023572 | 0.79 | MAPT (0.49) | MAPTHSD17B10ALDH1A1ERN1HIF1A | |
| SCHEMBL9654941 | 0.79 | MAPT (0.47) | MAPTHSD17B10ALDH1A1ERN1KDM4E | |
| SCHEMBL9657636 | 0.78 | AKR1B1 (0.45) | HIF1AEPAS1ALOX15LMNAALOX12 | |
| SCHEMBL28417984 | 0.76 | TUBB1 (0.63) | MAPTHSD17B10ALDH1A1KDM4EALOX15 | |
| SCHEMBL6495895 | 0.76 | BCHE (0.54) | MAPTHSD17B10ALDH1A1KDM4ELMNA | |
| SCHEMBL11064590 | 0.75 | MAPT (0.50) | MAPTHSD17B10ALDH1A1KDM4EALOX15 | |
| SCHEMBL9656536 | 0.75 | HIF1A (0.46) | MAPTHSD17B10ALDH1A1ERN1HIF1A | |
| SCHEMBL9654846 | 0.74 | CSNK2A2 (0.43) | MAPTHSD17B10ALDH1A1KDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |