Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.43 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 5/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657434 | 0.92 | CASR (0.51) | CYP1A2CYP3A4KDM4EALDH1A1ALOX15 | |
| SCHEMBL9657573 | 0.90 | PDE3B (0.46) | CYP1A2CYP3A4KDM4EALDH1A1ALOX15 | |
| SCHEMBL10567660 | 0.89 | PDE3B (0.45) | CYP1A2CYP3A4KDM4EALDH1A1ALOX15 | |
| SCHEMBL9654423 | 0.86 | MAPT (0.43) | CYP1A2CYP3A4KDM4EALDH1A1ALOX15 | |
| SCHEMBL9655863 | 0.85 | PDE3B (0.45) | CYP1A2CYP3A4KDM4EALDH1A1ALOX15 | |
| SCHEMBL9655814 | 0.85 | PDE3B (0.45) | CYP1A2CYP3A4KDM4EALDH1A1ALOX15 | |
| SCHEMBL9656799 | 0.85 | PDE3B (0.46) | CYP1A2CYP3A4KDM4EALDH1A1ALOX15 | |
| SCHEMBL9657696 | 0.85 | KDM4E (0.44) | CYP1A2CYP3A4KDM4EALDH1A1ALOX15 | |
| SCHEMBL9656654 | 0.85 | ADRB2 (0.47) | CYP1A2CYP3A4KDM4EALDH1A1ALOX15 | |
| SCHEMBL9657593 | 0.84 | PDE3B (0.45) | CYP1A2CYP3A4KDM4EALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259835-B1 | PYRIDAZINONE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1992-01-15 | — | — | EP | disclosed |
| US-4843072-A | Antihypertensive pyridazinone aminoisopropanol derivatives | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1989-06-27 | — | — | US | disclosed |
| EP-0259835-A2 | Pyridazinone derivatives | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1988-03-16 | — | — | EP | disclosed |