Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 4/20 | 0.59 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.59 |
| ▸ | GPR4 | P46093 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9655735 | 0.96 | AGTR2 (0.57) | AGTR2AGTR1 | |
| L-158809 SCHEMBL683357 | 0.89 | AGTR2 (0.71) | AGTR2AGTR1GPR4 | |
| SCHEMBL9655783 | 0.89 | AGTR2 (0.52) | AGTR2AGTR1 | |
| SCHEMBL9657763 | 0.88 | AGTR2 (0.47) | AGTR2AGTR1 | |
| L-158809 SCHEMBL7944169 | 0.88 | AGTR2 (0.70) | AGTR2AGTR1GPR4 | |
| SCHEMBL9658510 | 0.87 | AGTR2 (0.43) | AGTR2AGTR1 | |
| SCHEMBL9658890 | 0.86 | AGTR2 (0.45) | AGTR2AGTR1 | |
| SCHEMBL9657724 | 0.86 | AGTR2 (0.45) | AGTR2AGTR1 | |
| SCHEMBL9658834 | 0.86 | AGTR2 (0.53) | AGTR2AGTR1GPR4 | |
| SCHEMBL9657709 | 0.86 | AGTR2 (0.56) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510813-A1 | Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle | MERCK & CO. INC. (US) | 1992-10-28 | — | — | EP | claimed |
| EP-0510813-A1 | Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle | MERCK & CO. INC. (US) | 1992-10-28 | — | — | EP | disclosed |
| US-5128327-A | Hypotensive agents; congestive heart failure; antidepressants; anxiolytic agents; cognition activators | MERCK & CO., INC. (US) | 1992-07-07 | — | — | US | disclosed |