Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9659814 | 0.96 | ELANE (0.44) | ELANETSHRTDP1L3MBTL1CNR1 | |
| SCHEMBL9658432 | 0.95 | LMNA (0.44) | ELANETSHRCNR1CNR2SLC2A1 | |
| SCHEMBL9657998 | 0.95 | ELANE (0.46) | ELANETSHRTDP1L3MBTL1CNR1 | |
| SCHEMBL9656624 | 0.93 | ELANE (0.46) | ELANETSHRTDP1L3MBTL1CNR1 | |
| SCHEMBL9657686 | 0.92 | HTT (0.40) | ELANETSHRL3MBTL1CNR1CNR2 | |
| SCHEMBL9660585 | 0.91 | LMNA (0.45) | ELANETSHRCNR1CNR2SLC2A1 | |
| SCHEMBL9660341 | 0.90 | SLC2A1 (0.46) | ELANETSHRCNR1CNR2SLC2A1 | |
| SCHEMBL9659325 | 0.89 | ELANE (0.44) | ELANETSHRTDP1L3MBTL1CNR1 | |
| SCHEMBL9658382 | 0.89 | ELANE (0.47) | ELANETSHRTDP1L3MBTL1CNR1 | |
| SCHEMBL9659086 | 0.88 | SLC2A1 (0.41) | TSHRL3MBTL1CNR1CNR2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |