Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22314699 | 0.84 | MRGPRX4 (0.58) | MRGPRX4KCNH2NPC1RAB9ACYP19A1 | |
| SCHEMBL694568 | 0.76 | KCNH2 (0.53) | MRGPRX4KCNH2NPC1RAB9ALMNA | |
| SCHEMBL22315216 | 0.75 | KCNH2 (0.66) | MRGPRX4KCNH2NPC1RAB9ALMNA | |
| SCHEMBL29826138 | 0.75 | MRGPRX4 (0.64) | MRGPRX4NPC1RAB9AMAPTTDP1 | |
| SCHEMBL10980485 | 0.74 | HTT (0.47) | KCNH2MAOBMEN1KMT2ATSHR | |
| SCHEMBL22315218 | 0.73 | NPC1 (0.49) | MRGPRX4KCNH2NPC1RAB9ACYP19A1 | |
| SCHEMBL28789092 | 0.72 | MRGPRX4 (0.51) | MRGPRX4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL22481085 | 0.72 | MRGPRX4 (1.00) | MRGPRX4KCNH2PDE5A | |
| SCHEMBL22314702 | 0.71 | MRGPRX4 (0.45) | MRGPRX4KCNH2NPC1RAB9ALMNA | |
| SCHEMBL22314722 | 0.71 | MRGPRX4 (0.48) | MRGPRX4KCNH2NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241918-B1 | 1-HYDROXY-2-PYRIDINONES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM, AS WELL AS INTERMEDIATES FORMED BY THE PREPARATION OF 1-HYDROXY-2-PYRIDINONES | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4797409-A | FUNGICIDES, YEAST INFECTIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-10 | — | — | US | disclosed |
| EP-0241918-A2 | 1-Hydroxy-2-pyridinones, process for their preparation and medicines containing them, as well as intermediates formed by the preparation of 1-hydroxy-2-pyridinones | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-10-21 | — | — | EP | disclosed |