Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 13/20 | 0.43 |
| ▸ | VHL | P40337 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19791266 | 0.77 | VHL (0.44) | VHLMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL11346905 | 0.75 | VHL (0.46) | VHLMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL9658558 | 0.74 | NOTUM (0.56) | FDPSMEN1KMT2APOLB | |
| SCHEMBL803419 | 0.72 | MEN1 (0.46) | VHLMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL18994354 | 0.69 | MEN1 (0.43) | VHLMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL1698651 | 0.68 | VHL (0.58) | VHLMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL2093204 | 0.68 | — | — | |
| SCHEMBL19399866 | 0.68 | — | — | |
| SCHEMBL2093209 | 0.68 | — | — | |
| SCHEMBL4204403 | 0.67 | EPHX2 (0.57) | VHLMEN1KMT2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0258618-B1 | DIPHOSPHONIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THOSE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |
| US-4777163-A | BONE DISORDERS, RHEUMATIC DISEASES | BOEHRINGER MANNHEIM GMBH (DE) | 1988-10-11 | — | — | US | disclosed |
| EP-0258618-A2 | Diphosphonic acid derivatives, process for their preparation and medicines containing those compounds | Roche Diagnostics GmbH (DE) | 1988-03-09 | — | — | EP | disclosed |