Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.56 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | FDPS | P14324 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10475736 | 0.79 | NOTUM (0.63) | NOTUMNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL13819899 | 0.75 | NOTUM (0.62) | NOTUMNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL9657404 | 0.74 | FDPS (0.43) | FDPSMEN1KMT2APOLB | |
| SCHEMBL24459722 | 0.73 | NOTUM (0.68) | NOTUMNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1313626 | 0.73 | NOTUM (1.00) | NOTUMNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4142743 | 0.72 | NOTUM (0.67) | NOTUMNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL13827642 | 0.72 | NOTUM (0.57) | NOTUMNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6401623 | 0.72 | NOTUM (0.61) | NOTUMNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL9656852 | 0.71 | NOTUM (0.56) | NOTUMGGPS1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL512927 | 0.70 | MEN1 (0.55) | NOTUMNPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0258618-B1 | DIPHOSPHONIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THOSE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |
| US-4777163-A | BONE DISORDERS, RHEUMATIC DISEASES | BOEHRINGER MANNHEIM GMBH (DE) | 1988-10-11 | — | — | US | disclosed |
| EP-0258618-A2 | Diphosphonic acid derivatives, process for their preparation and medicines containing those compounds | Roche Diagnostics GmbH (DE) | 1988-03-09 | — | — | EP | disclosed |