Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 13/20 | 0.67 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.47 |
| ▸ | HPD | P32754 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9656734 | 0.91 | IDH1 (0.67) | IDH1MAOBMAOANR4A2GRM5 | |
| SCHEMBL10563264 | 0.88 | IDH1 (0.63) | IDH1MAOBMAOANR4A2GRM5 | |
| SCHEMBL9658531 | 0.87 | IDH1 (0.61) | IDH1GRM5 | |
| SCHEMBL10726777 | 0.86 | IDH1 (0.74) | IDH1 | |
| SCHEMBL9656775 | 0.86 | IDH1 (0.52) | IDH1MAOBMAOANR4A2GRM5 | |
| SCHEMBL14140191 | 0.85 | IDH1 (0.66) | IDH1 | |
| SCHEMBL9656761 | 0.84 | IDH1 (0.61) | IDH1 | |
| SCHEMBL10724015 | 0.83 | IDH1 (0.79) | IDH1 | |
| SCHEMBL9657990 | 0.83 | IDH1 (0.57) | IDH1 | |
| SCHEMBL9656751 | 0.83 | IDH1 (0.69) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241918-B1 | 1-HYDROXY-2-PYRIDINONES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM, AS WELL AS INTERMEDIATES FORMED BY THE PREPARATION OF 1-HYDROXY-2-PYRIDINONES | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4797409-A | FUNGICIDES, YEAST INFECTIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-10 | — | — | US | disclosed |
| EP-0241918-A2 | 1-Hydroxy-2-pyridinones, process for their preparation and medicines containing them, as well as intermediates formed by the preparation of 1-hydroxy-2-pyridinones | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-10-21 | — | — | EP | disclosed |