Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ACE | P12821 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9658400 | 1.00 | REN (0.49) | RENATMKMT2AACEMEN1 | |
| SCHEMBL12137049 | 0.84 | ATM (0.61) | RENATMKMT2AACEMEN1 | |
| SCHEMBL2736190 | 0.84 | ATM (0.61) | RENATMKMT2AACEMEN1 | |
| SCHEMBL9659216 | 0.79 | ACE (0.56) | RENATMKMT2AACEMEN1 | |
| SCHEMBL7323815 | 0.79 | ACE (0.56) | RENATMKMT2AACEMEN1 | |
| SCHEMBL7323810 | 0.79 | ACE (0.56) | RENATMKMT2AACEMEN1 | |
| SCHEMBL9659207 | 0.79 | ACE (0.56) | RENATMKMT2AACEMEN1 | |
| SCHEMBL11512962 | 0.79 | ACE (0.62) | ATMKMT2AACEMEN1MAPK1 | |
| SCHEMBL11374461 | 0.79 | ACE (0.62) | ATMKMT2AACEMEN1MAPK1 | |
| SCHEMBL23156370 | 0.79 | ATM (0.56) | RENATMKMT2AACEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130468-A | Process for the preparation of a dipeptide isostere | ABBOTT LABORATORIES (US) | 1992-07-14 | — | — | US | disclosed |