Bromide

Bromide

SCHEMBL9659504

Br.CCOC(=O)/C(=N/OC)c1csc(N)n1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.58
MEN1 O00255 5/20 0.58
KMT2A Q03164 5/20 0.58
ALDH1A1 P00352 3/20 0.58
NPC1 O15118 1/20 0.58
RAB9A P51151 1/20 0.58
TDP1 Q9NUW8 4/20 0.54
LMNA P02545 2/20 0.54
MAPK1 P28482 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
ITGB1 P05556 1/20 0.45
ITGA4 P13612 1/20 0.45
GAA P10253 3/20 0.43
NPSR1 Q6W5P4 2/20 0.43
RECQL P46063 1/20 0.43
NR1I2 O75469 3/20 0.42
PGR P06401 1/20 0.42
PTGS2 P35354 1/20 0.42
TSHR P16473 2/20 0.41
ALB P02768 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL9659508 1.00 MAPT (0.58) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL9076641 0.99 MAPT (0.59) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL1143128 0.99 MAPT (0.59) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL1143127 0.99 MAPT (0.59) MAPTMEN1KMT2AALDH1A1NPC1
Bromide SCHEMBL9075329 0.90 MAPT (0.62) MAPTMEN1KMT2AALDH1A1NPC1
Bromide SCHEMBL9075332 0.90 MAPT (0.62) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL8645013 0.88 MAPT (0.63) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL10538827 0.88 MAPT (0.63) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL8645016 0.88 MAPT (0.63) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL11102898 0.87 MAPT (0.48) MAPTMEN1KMT2AALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5079369-A N-acylating agent FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1992-01-07 US disclosed
US-4877873-A BACTERICIDES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1989-10-31 US disclosed
US-4871860-A Syn-isomer of 3,7-disubstituted-3-cephem-4-caroxylic acid compounds and processes for the preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1989-10-03 US disclosed
US-4804752-A BACTERICIDES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1989-02-14 US disclosed
US-4544653-A BACTERICIDAL CEPHALOSPORINS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1985-10-01 US disclosed
US-4493833-A BACTERICIDES, ANTIBIOTICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1985-01-15 US disclosed
US-4431643-A CEPHALOSPORINS; BACTERICIDES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1984-02-14 US disclosed
US-4364943-A CEPHALOSPORINS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1982-12-21 US disclosed
US-4331664-A BACTERIOSTATS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1982-05-25 US disclosed
US-4316019-A AMIDATION BY A 2-ALKOXYIMINO-2-THIAZOLYLACETIC ACID FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1982-02-16 US disclosed
US-4304770-A Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1981-12-08 US disclosed
US-4299829-A MICROBIOCIDES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1981-11-10 US disclosed
US-4279818-A CEPHALOSPORINS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1981-07-21 US disclosed
US-4225707-A 2-Lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compounds FUJISAWA PHARMACEUTICAL COMPANY, LIMITED (JP) 1980-09-30 US disclosed
US-4166115-A BACTERICIDES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1979-08-28 US disclosed
US-4152433-A ANTIBIOTICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1979-05-01 US disclosed