Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 2/20 | 0.62 |
| ▸ | PNP | P00491 | 7/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | EDNRA | P25101 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HBB | P68871 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | VCP | P55072 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HPRT1 | P00492 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10665232 | 1.00 | TK1 (0.62) | TK1PNPBLMUSP2TSHR | |
| SCHEMBL9663133 | 0.85 | TK1 (0.64) | TK1PNPBLMUSP2TSHR | |
| SCHEMBL9663138 | 0.85 | TK1 (0.64) | TK1PNPBLMUSP2TSHR | |
| SCHEMBL10506159 | 0.83 | TK1 (0.71) | TK1PNPBLMUSP2TSHR | |
| SCHEMBL10506150 | 0.83 | TK1 (0.71) | TK1PNPBLMUSP2TSHR | |
| SCHEMBL10508175 | 0.83 | TK1 (0.71) | TK1PNPBLMUSP2TSHR | |
| SCHEMBL933142 | 0.82 | TK1 (0.67) | TK1PNPBLMUSP2TSHR | |
| SCHEMBL23892740 | 0.79 | TK1 (0.70) | TK1PNPBLMUSP2TSHR | |
| SCHEMBL11374638 | 0.79 | HPRT1 (0.67) | TK1PNPHPRT1 | |
| SCHEMBL1732928 | 0.79 | HPRT1 (0.67) | TK1PNPHPRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0173624-B1 | 4-(GUANIN-9-YL) BUTANALS AND ANTIVIRAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1992-04-08 | — | — | EP | disclosed |
| US-4755516-A | Antiviral compounds | MERCK & CO., INC. (US) | 1988-07-05 | — | — | US | disclosed |
| EP-0173624-A2 | 4-(guanin-9-yl) butanals and antiviral compositions containing them | MERCK & CO. INC. (US) | 1986-03-05 | — | — | EP | disclosed |